|
KMID : 0381020060390080756
|
|
Korean Journal of Nutrition
2006 Volume.39 No. 8 p.756 ~ p.761
|
|
|
Effect of Curcumin on Cancer Invasion and Matrix Metalloproteinase-9 Activity in MDA-MB-231 Human Breast Cancer Cell
|
|
Bang Myung-Hee
Kim Woo-Kyung
|
|
|
Abstract
|
|
|
|
Curcumin has been known for its anti-proliferative and apoptotic effects on several cancer cells. We examined the inhibitory effects of curcumin on cancer cell adhesion, motility, invasion and matrix metalloproteinase-9 (MMP-9) activity in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured with 0, 5, 10 or $20{\mu}M$ of curcumin. Curcumin significantly inhibited the adhesion of cancer cells to the fibronectin at $20{\mu}M$ and suppressed the motility and invasion of cancer cells at all concentrations. Also, the MMP-9 activity was inhibited by curcumin, but MMP-9 protein amounts were not affected. Our data indicate that curcumin inhibits motility, invasion and MMP-9 activity of MDA-MB-231 cells. Therefore, curcumin may contribute to the potential beneficial food component to prevent the cancer metastasis in human breast cancer.
|
|
|
KEYWORD
|
|
|
curcumin, invasion, matrix metalloproteinase-9, metastasis, breast cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|